Run Amuck Slot

Review of Run Amuck Online Slot

The Run Amuck online slot features a colorful array of potions and cartoon bacteria on a large 7×7 symbol grid nestled in a laboratory with animated machinery. Winning combinations are formed by matching symbols in clusters.

This game offers a Racking up Riches feature along with free spins, where symbols collapse into a single position, creating high-value symbols that can repeat the process multiple times.

You can enjoy playing the Run Amuck slot online on both PCs and mobile devices at the top High 5 Games sites and unleash the friendly bugs.

Explore the Laboratory

If you appreciate cartoon-style games brimming with humor, don’t miss out on this one. From the lively microbes to the upbeat soundtrack, everything adds to the entertainment. You get a top-down view of a 7×7 grid surrounded by peculiar contraptions in the laboratory of a mad scientist.

The grid features four colorful beakers and bottles, along with green, orange, purple, and blue bacteria. The lower-paying symbols can appear as singles, doubles, or triples in one spot, while the bug-eyed bugs can transform into baby forms or all-singing, all-dancing grown-up versions. Whether you call them bacteria, germs, or microbes, they are sure to bring a smile to your face when you see them on the Run Amuck slot machine grid.

This game is developed by the US-based High 5 Games, known for popular titles like Secrets of the Forest and the Da Vinci Diamonds series.

Dive into the Petri Dish

You can wager anywhere from a low limit of 0.20 to a generous 400.00 per spin. The Run Amuck online slot operates on a cluster pays system, requiring four or more matching symbols grouped together to achieve a win.

The game involves playing with 20 coins and offers coin multipliers. A paylines table details the payouts for clusters ranging from four to 48 matching symbols.

The game can be played in Autoplay mode for up to 100 rounds, but it’s advisable to set a loss limit due to its high volatility. The prizes are typically significant to compensate for this. The average payback percentage of 96% is decent but not exceptional.

Collapse the Clusters

The Run Amuck slot machine showcases the Racking up Riches feature by High 5 Games. Clusters of two or three test tubes or baby bacteria collapse into a single position, forming matched tubes or babies.

Once all symbols have collapsed as far as possible, non-winning symbols disappear, making way for new symbols. If these new symbols can also collapse into four tubes or grown-up bacteria, the process repeats until no new combinations can be formed. At this point, all combinations are evaluated, and you receive your payouts.

A special bonus symbol in the form of brightly lit lab equipment appears in corner positions and awards eight or 30 free games for landing three or four examples. Before each free spin, groups of test tubes or adult microbes appear in random spots to kick-start clusters.

Discover More Bug-Themed Games

Cyrus the Virus by Yggdrasil is another slot featuring a plethora of colorful cartoon bugs across five reels and five lines. The purple Cyrus serves as an angry wild symbol that expands over reels before triggering respins.

For more cartoon microbes, check out the Germinator slot machine by Microgaming, played on a 6×6 grid with 12 lines and a cascading reels system that removes germ lines using bonus pill symbols.

A Wholesome Game

The animated antics of the germs in the Run Amuck slot machine make it visually appealing and fast-paced, with frequent collapsing clusters. Observing the exciting Racking up Riches feature in action can lead to substantial winnings.

As symbols cascade into each other, anticipating further collapses becomes easier, especially during the free games feature, which has the potential to yield significant wins.

Experience the gameplay of Run Amuck slot for free here to familiarize yourself with its mechanics before joining the pathogen party at top High 5 Games casinos.

Jesse Miller iGaming Writer

Last Updated: September 27, 2025